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seq2PRINT\uff0c\u80fd\u591f\u6355\u6349\u5230\u8fd9\u79cd\u4ed6\u4eec\u9884\u5224\u5df2\u4e45\u7684\u4f9d\u8d56\u5173\u7cfb\uff0c\u5e76\u4e14\u53ef\u4ee5\u51c6\u786e\u5730\u9884\u6d4b\u5230\u201c\u9690\u5f62\u201d\u8f6c\u5f55\u56e0\u5b50\u7684\u7ed3\u5408\u4f4d\u7f6e\u3002\u540c\u65f6\uff0c\u8fd9\u4e5f\u662f\u56e0\u4e3a\u4ed6\u4eec\u6700\u5f00\u59cb\u6784\u5efa seq2PRINT \u53ea\u662f\u4e3a\u4e86\u7814\u7a76 DNA \u5e8f\u5217\u548c\u86cb\u767d\u7ed3\u5408\u7684\u4f9d\u8d56\u5173\u7cfb\uff0c\u800c\u5e76\u4e0d\u662f\u4e3a\u4e86\u9884\u6d4b\u8f6c\u5f55\u56e0\u5b50\u7684\u7ed3\u5408\u3002\u201c\u6240\u4ee5\uff0c\u8fd9\u4e5f\u7b97\u662f\u901a\u8fc7\u975e\u5e38\u9884\u6599\u4e4b\u5916\u7684\u65b9\u5f0f\u89e3\u51b3\u4e86\u6211\u4eec\u7684\u95ee\u9898\u3002\u201d\u80e1\u5f66\u8868\u793a\u3002\u65e5\u524d\uff0c\u76f8\u5173\u8bba\u6587\u4ee5\u300a\u591a\u5c3a\u5ea6\u8db3\u8ff9\u63ed\u793a\u4e86\u987a\u5f0f\u8c03\u63a7\u5143\u4ef6\u7684\u7ec4\u7ec7\u300b\uff08Multiscale footprints reveal the organization of cis-regulatory elements\uff09\u4e3a\u9898\u53d1\u5728&nbsp;Nature[1]\uff0c\u535a\u58eb\u751f\u80e1\u5f66\u3001\u535a\u58eb\u540e\u5f20\u82e5\u9a70\u3001\u535a\u58eb\u540e\u9ea6\u514b\u601d\u00b7\u970d\u5c14\u8d1d\u514b\uff08Max Horlbeck \uff09\u4e3a\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u54c8\u4f5b\u5927\u5b66\u6770\u68ee\u00b7D\u00b7\u5e03\u6069\u7f57\u65af\u6258\uff08Jason D. Buenrostro\uff09\u6559\u6388\u62c5\u4efb\u901a\u8baf\u4f5c\u8005\u3002\u56fe | \u76f8\u5173\u8bba\u6587\uff08\u6765\u6e90\uff1aNature\uff09\u672a\u6765\uff0c\u80e1\u5f66\u5e0c\u671b\u80fd\u5c06\u672c\u6b21\u6280\u672f\u7528\u4e8e\u4eba\u7c7b\u75be\u75c5\u7814\u7a76\uff0c\u4f8b\u5982\u5fc3\u8840\u7ba1\u75be\u75c5\u9886\u57df\uff0c\u5373\u7814\u7a76\u57fa\u56e0\u8c03\u63a7\u5143\u4ef6\u548c\u8f6c\u5f55\u56e0\u5b50\u5728\u5fc3\u8840\u7ba1\u75be\u75c5\uff0c\u5c24\u5176\u662f\u7814\u7a76\u8870\u8001\u76f8\u5173\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\u3002\u540c\u65f6\uff0c\u5176\u5e0c\u671b\u901a\u8fc7\u5c06\u672c\u6b21\u6280\u672f\u7528\u4e8e\u5fc3\u8840\u7ba1\u7cfb\u7edf\u7684\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u6570\u636e\uff0c\u6765\u7814\u7a76\u5230\u5e95\u662f\u54ea\u4e9b\u57fa\u56e0\u3001\u54ea\u4e9b\u901a\u8def\u548c\u54ea\u4e9b\u8f6c\u5f55\u56e0\u5b50\u53c2\u4e0e\u4e86\u75be\u75c5\u53d1\u751f\u548c\u53d1\u5c55\u7684\u91cd\u8981\u6b65\u9aa4\u3002\u6700\u7ec8\uff0c\u5176\u5e0c\u671b\u53ef\u4ee5\u5f00\u53d1\u51fa\u80fd\u591f\u9884\u9632\u6216\u6cbb\u7597\u8870\u8001\u76f8\u5173\u75be\u75c5\u7684\u65b0\u65b9\u6cd5\u3002\u53c2\u8003\u8d44\u6599\uff1a1.Hu, Y., Horlbeck, M.A., Zhang, R. et al. Multiscale footprints reveal the organization of cis-regulatory elements.&nbsp;Nature&nbsp;638, 779\u2013786 (2025). https:\/\/doi.org\/10.1038\/s41586-024-08443-4\u8fd0\u8425\/\u6392\u7248\uff1a\u4f55\u6668\u9f99","content":"<p style=\"caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);\"><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u8fd1\u65e5\uff0c\u7f8e\u56fd\u54c8\u4f5b\u5927\u5b66\u535a\u58eb\u751f\u80e1\u5f66\u548c\u6240\u5728\u56e2\u961f\u5f00\u53d1\u51fa\u4e00\u79cd\u65b0\u578b\u8ba1\u7b97\u751f\u7269\u5b66\u6280\u672f\uff0c<\/span><strong><span style=\"color: rgb(14, 23, 50); --tt-darkmode-color: #94A2CE;\">\u80fd\u4ee5\u9ad8\u901a\u91cf\u7684\u65b9\u5f0f\u7cbe\u51c6\u9884\u6d4b\u6570\u4ee5\u767e\u8ba1\u7684\u8f6c\u5f55\u56e0\u5b50\u5728\u4e0a\u767e\u79cd\u7ec6\u80de\u72b6\u6001\u6216\u7ec6\u80de\u7c7b\u578b\u5185\u7684\u7ed3\u5408\u4f4d\u7f6e\uff0c\u4ece\u800c\u80fd\u591f\u52a9\u529b\u4e8e\u66f4\u6709\u6548\u5730\u89e3\u7801\u7ec6\u80de\u5185\u7684\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\uff0c<\/span><\/strong>\u76f8\u5173\u8bba\u6587\u4e8e\u8fd1\u671f\u53d1\u8868\u5728&nbsp;<\/span><em><span style=\"letter-spacing: 1px;\">Nature<\/span><\/em><span style=\"letter-spacing: 1px;\">\u3002<\/span><\/p><p style=\"caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);\"><\/p><p style=\"caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);\"><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u5177\u4f53\u800c\u8a00\uff0c\u7814\u7a76\u56e2\u961f\u5229\u7528\u4e00\u79cd\u540d\u4e3a ATAC-seq \u7684\u5df2\u6709\u6280\u672f\uff0c\u4f7f\u7528\u4e00\u79cd\u540d\u4e3a Tn5 \u7684\u9176\u5207\u5272 DNA\uff0c\u5e76\u4e14\u901a\u8fc7\u6d4b\u5e8f\u6280\u672f\u786e\u5b9a\u5207\u5272\u7684\u4f4d\u7f6e\u3002\u901a\u8fc7\u4ee5\u5355\u78b1\u57fa\u5bf9\u7684\u5206\u8fa8\u7387\u5206\u6790 DNA \u4e0a\u6bcf\u4e2a\u4f4d\u7f6e\u88ab\u5207\u5272\u7684\u9891\u7387\uff0c\u4ed6\u4eec\u53d1\u73b0 DNA \u4e0a\u6ca1\u6709\u88ab\u8f6c\u5f55\u56e0\u5b50\u6216\u5176\u4ed6\u8c03\u63a7\u86cb\u767d\u7ed3\u5408\u7684\u533a\u57df\uff0c\u7531\u4e8e\u66f4\u52a0\u66b4\u9732\u4f1a\u66f4\u5bb9\u6613\u88ab\u5207\u5272\uff0c\u56e0\u6b64\u4f1a\u663e\u73b0\u8f83\u9ad8\u7684\u5207\u5272\u9891\u7387\u3002DNA \u4e0a\u88ab\u8f6c\u5f55\u56e0\u5b50\u6216\u5176\u4ed6\u8c03\u63a7\u86cb\u767d\u7ed3\u5408\u7684\u533a\u57df\uff0c\u4f1a\u88ab\u7ed3\u5408\u7684\u86cb\u767d\u6240\u4fdd\u62a4\u4ee5\u53ca\u906e\u6321\uff0c\u5bfc\u81f4 Tn5 \u65e0\u6cd5\u6709\u6548\u5207\u5272\u8fd9\u4e9b\u533a\u57df\uff0c\u800c\u8fd9\u4e9b\u533a\u57df\u4e5f\u56e0\u6b64\u663e\u73b0\u51fa\u8f83\u4f4e\u7684\u5207\u5272\u9891\u7387\uff0c\u4ece\u800c\u5f62\u6210\u4f4e\u5207\u5272\u9891\u7387\u7684\u201c\u811a\u5370\u201d\uff0c\u8fd9\u4e2a\u65b9\u6cd5\u4e5f\u56e0\u6b64\u88ab\u79f0\u4e3a DNA \u8db3\u8ff9\u6cd5\u3002<\/span><\/span><\/p><p style=\"caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);\"><\/p><div style=\"caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);\"><img src=\"https:\/\/p3-sign.toutiaoimg.com\/tos-cn-i-6w9my0ksvp\/aea82336b7b94fca87f008373ab8afcf~tplv-obj.image?lk3s=ef143cfe&amp;traceid=20250512094914DF4955DFF708A2F84BC6&amp;x-expires=2147483647&amp;x-signature=kIrrEfeEWfhV8lreRlMJATGpVe0%3D\"\/>\uff08\u6765\u6e90\uff1a\u80e1\u5f66\uff09<\/div><div style=\"caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);\"><br\/><a><\/a><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u901a\u8fc7\u627e\u5230\u8fd9\u4e9b\u5207\u5272\u9891\u7387\u8f83\u4f4e\u7684\u533a\u57df\uff0c\u4fbf\u53ef\u4ee5\u786e\u5b9a\u8c03\u63a7\u86cb\u767d\u7684\u7ed3\u5408\u4f4d\u70b9\u3002\u6253\u4e2a\u6bd4\u65b9\uff0c\u4e0b\u96e8\u5929\u88ab\u6811\u906e\u6321\u7684\u5730\u65b9\u4e0d\u4f1a\u88ab\u96e8\u6253\u6e7f\uff0c\u800c\u4e0d\u88ab\u906e\u6321\u7684\u5730\u65b9\u5730\u9762\u5219\u4f1a\u6e7f\u900f\u3002\u5982\u679c\u4e0d\u80fd\u76f4\u63a5\u89c2\u5bdf\u5230\u6811\u7684\u4f4d\u7f6e\uff0c\u53ef\u4ee5\u901a\u8fc7\u89c2\u5bdf\u5730\u9762\u54ea\u4e9b\u533a\u57df\u662f\u5e72\u71e5\u7684\u6765\u786e\u5b9a\u6811\u5728\u54ea\u91cc\u3002\u6b63\u56e0\u6b64\uff0c\u8bfe\u9898\u7ec4\u5c06\u672c\u6b21\u6280\u672f\u79f0\u4e3a PRINT\uff08protein\u2013regulatory element interactions at nucleotide resolution using transposition\uff09\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u5728\u89c2\u6d4b\u5230\u4e00\u4e2a\u8f6c\u5f55\u56e0\u5b50\u7559\u4e0b\u7684\u201c\u811a\u5370\u201d\u540e\uff0c\u5982\u4f55\u786e\u5b9a\u5230\u5e95\u662f\u54ea\u4e2a\u8f6c\u5f55\u56e0\u5b50\u7ed3\u5408\u7684\uff1f\u4e8b\u5b9e\u4e0a\uff0c\u4e0d\u540c\u8f6c\u5f55\u56e0\u5b50\u5728\u7ed3\u5408 DNA \u7684\u65f6\u5019\u4f1a\u8bc6\u522b\u4e0d\u540c\u7684 DNA \u5e8f\u5217\uff0c\u901a\u8fc7\u6bd4\u5bf9\u811a\u5370\u4e0b\u65b9\u7684 DNA \u5e8f\u5217\uff0c\u53ef\u4ee5\u6bd4\u8f83\u51c6\u786e\u5730\u5224\u65ad\u6240\u7ed3\u5408\u7684\u5230\u5e95\u662f\u54ea\u4e00\u4e2a\u6216\u54ea\u4e00\u7c7b\u8f6c\u5f55\u56e0\u5b50\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u7814\u7a76\u4e2d\u53d1\u73b0\uff0cTn5 \u672c\u8eab\u5bf9\u4e8e\u5207\u5272\u4e0d\u540c\u7684 DNA \u5e8f\u5217\u6709\u7740\u8f83\u4e3a\u660e\u663e\u7684\u504f\u597d\uff0c\u8fd9\u4e5f\u5bf9\u8f6c\u5f55\u56e0\u5b50\u7ed3\u5408\u7684\u68c0\u6d4b\u9020\u6210\u4e86\u6781\u5927\u7684\u5e72\u6270\u3002\u4e3a\u6b64\uff0c\u56e2\u961f\u6210\u5458\u4f7f\u7528\u795e\u7ecf\u7f51\u7edc\u6a21\u578b\u9488\u5bf9 Tn5 \u7684\u5e8f\u5217\u504f\u597d\u8fdb\u884c\u5efa\u6a21\uff0c\u5e76\u4e14\u5c06\u5176\u9020\u6210\u7684\u5e72\u6270\u6709\u6548\u53bb\u9664\uff0c\u4ee5\u4fbf\u80fd\u591f\u51c6\u786e\u5730\u89c2\u5bdf\u5230\u771f\u6b63\u8f6c\u5f55\u56e0\u5b50\u7ed3\u5408\u7559\u4e0b\u7684\u811a\u5370\uff0c\u5e76\u4e14\u80fd\u591f\u6d4b\u5b9a\u8f6c\u5f55\u56e0\u5b50\u7684\u7ed3\u5408\u4f4d\u7f6e\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u6b64\u5916\uff0c\u5373\u4f7f\u5728\u540c\u4e00\u4e2a DNA \u8c03\u63a7\u5143\u4ef6\u5185\uff0c\u4e0d\u540c DNA \u7ed3\u5408\u86cb\u767d\u7684\u5c3a\u5bf8\u4e5f\u6709\u53ef\u80fd\u4f1a\u76f8\u5dee\u751a\u8fdc\u3002\u53d7\u5230\u4fe1\u53f7\u5904\u7406\u9886\u57df\u5c0f\u6ce2\u5206\u6790\u7684\u542f\u53d1\uff0c<\/span><strong><span style=\"color: rgb(14, 23, 50); --tt-darkmode-color: #94A2CE;\">\u4ed6\u4eec\u4f7f\u7528\u4e0d\u540c\u534a\u5f84\u7684\u533a\u95f4\u6765\u68c0\u6d4b\u86cb\u767d\u7ed3\u5408\u7684\u811a\u5370\uff0c\u501f\u6b64\u5b9e\u73b0\u4e86\u5bf9\u4e8e\u4e0d\u540c\u7269\u7406\u5c3a\u5bf8\u7684 DNA \u7ed3\u5408\u86cb\u767d\u7684\u540c\u65f6\u68c0\u6d4b\u3002<\/span><\/strong><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u6b63\u56e0\u6b64\uff0c\u5728\u540c\u4e00\u4e2a DNA \u533a\u57df\u5185\u4ed6\u4eec\u53ef\u4ee5\u89c2\u5bdf\u5230\u4e0b\u81f3\u8f6c\u5f55\u56e0\u5b50\u3001\u4e0a\u81f3\u6838\u5c0f\u4f53\u5728 DNA \u4e0a\u7684\u7ed3\u5408\u3002\u57fa\u4e8e\u6b64\uff0c\u4ed6\u4eec\u5c06\u8fd9\u4e00\u65b9\u6cd5\u79f0\u4e4b\u4e3a\u591a\u5c3a\u5ea6\u8db3\u8ff9\u6cd5\uff08multiscale footprinting\uff09\u3002<\/span><\/span><\/p><div><img src=\"https:\/\/p3-sign.toutiaoimg.com\/tos-cn-i-6w9my0ksvp\/5978e4cd40914f18a7c61c85ce0acda0~tplv-obj.image?lk3s=ef143cfe&amp;traceid=20250512094914DF4955DFF708A2F84BC6&amp;x-expires=2147483647&amp;x-signature=sotCXVTNdSD45Cbr0na3fTU8CM4%3D\"\/>\u56fe | PRINT \u7684\u6d41\u7a0b\u793a\u610f\u56fe\uff08\u6765\u6e90\uff1aNature\uff09<\/div><div><br\/><a><\/a><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u7814\u7a76\u4e2d\uff0c\u4ed6\u4eec\u66f4\u8fdb\u4e00\u6b65\u5730\u601d\u8003\uff1aDNA \u5e8f\u5217\u5728\u591a\u5927\u7a0b\u5ea6\u4e0a\u51b3\u5b9a\u4e86\u8c03\u63a7\u86cb\u767d\u7684\u7ed3\u5408\u4f4d\u7f6e\uff1f\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c\u4ed6\u4eec\u8bad\u7ec3\u51fa\u4e00\u6b3e\u540d\u4e3a seq2PRINT \u7684\u6df1\u5ea6\u5b66\u4e60\u795e\u7ecf\u7f51\u7edc\u6a21\u578b\uff0c\u5c1d\u8bd5\u4f7f\u7528 DNA \u5e8f\u5217\u4f5c\u4e3a\u6a21\u578b\u7684\u552f\u4e00\u8f93\u5165\u6765\u9884\u6d4b\u540c\u4e00\u533a\u57df\u5185\u86cb\u767d\u8d28\u7ed3\u5408\u7684\u4f4d\u7f6e\u548c\u5f3a\u5ea6\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u501f\u6b64\u53d1\u73b0\uff1a\u4ec5\u4ec5\u7528 DNA \u5e8f\u5217\uff0cseq2PRINT \u4fbf\u53ef\u4ee5\u8f83\u4e3a\u51c6\u786e\u5730\u9884\u6d4b\u4e0d\u540c\u86cb\u767d\u8d28\u7684\u7ed3\u5408\u3002\u901a\u8fc7\u63d0\u53d6\u6a21\u578b\u5b66\u4e60\u5230\u7684\u5e8f\u5217\u7279\u5f81\uff0c\u4ed6\u4eec\u53d1\u73b0 seq2PRINT \u4e3b\u8981\u4f9d\u8d56\u533a\u57df\u5185\u7684\u8f6c\u5f55\u56e0\u5b50\u8bc6\u522b\u5e8f\u5217\u7684\u4f4d\u7f6e\u6392\u5e03\uff0c\u6765\u9884\u6d4b\u5404\u79cd\u86cb\u767d\u5305\u62ec\u6838\u5c0f\u4f53\u7684\u7ed3\u5408\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u4ee4\u4ed6\u4eec\u975e\u5e38\u610f\u5916\u7684\u662f\uff0cseq2PRINT \u51c6\u786e\u5730\u6355\u6349\u5230\u4e86\u88ab\u8f6c\u5f55\u56e0\u5b50\u7ed3\u5408\u7684\u5e8f\u5217\uff08\u5373\u4f7f\u662f\u672c\u8eab\u5e76\u4e0d\u7559\u4e0b\u4efb\u4f55\u811a\u5370\u7684\u8f6c\u5f55\u56e0\u5b50\uff09\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u8fd9\u4e00\u70b9\u683c\u5916\u503c\u5f97\u5f3a\u8c03\uff0c\u56e0\u4e3a\u8bb8\u591a\u8f6c\u5f55\u56e0\u5b50\u7ed3\u5408 DNA \u8981\u4e48\u975e\u5e38\u77ed\u6682\u3001\u8981\u4e48\u7ed3\u5408\u5f3a\u5ea6\u8f83\u5f31\uff0c\u8fd9\u5c31\u5bfc\u81f4\u5b83\u4eec\u5e76\u4e0d\u80fd\u6709\u6548\u5730\u4fdd\u62a4\u7ed3\u5408\u4e4b\u540e\u7684 DNA \u53bb\u907f\u5f00 Tn5 \u5207\u5272\uff0c\u8fdb\u800c\u5bfc\u81f4\u8fd9\u4e9b\u8f6c\u5f55\u56e0\u5b50\u65e0\u6cd5\u964d\u4f4e Tn5 \u5207\u5272\u7684\u9891\u7387\uff0c\u4e5f\u4e0d\u80fd\u7559\u4e0b\u53ef\u89c1\u7684\u811a\u5370\uff0c\u4ee5\u81f3\u4e8e\u6210\u4e3a\u4e86\u201c\u9690\u5f62\u201d\u7684\u8f6c\u5f55\u56e0\u5b50\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u901a\u8fc7\u4f20\u7edf\u7684 DNA \u8db3\u8ff9\u6cd5\uff0c\u5f88\u96be\u68c0\u6d4b\u8fd9\u4e9b\u56e0\u5b50\u7684\u7ed3\u5408\u3002\u7136\u800c\uff0c\u57fa\u4e8e DNA \u5e8f\u5217\u7684\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\uff0c\u901a\u8fc7\u6355\u6349\u8fd9\u4e9b\u201c\u9690\u5f62\u201d\u8f6c\u5f55\u56e0\u5b50\u7684\u8bc6\u522b\u5e8f\u5217\u4ee5\u53ca\u9644\u8fd1\u53ef\u89c1\u7684\u86cb\u767d\u811a\u5370\u4e4b\u95f4\u7684\u4f9d\u8d56\u5173\u7cfb\uff0c\u53ef\u4ee5\u6709\u6548\u6355\u6349\u5230\u8fd9\u4e9b\u201c\u9690\u5f62\u201d\u8f6c\u5f55\u56e0\u5b50\u7684\u5b58\u5728\uff0c\u8fdb\u800c\u80fd\u591f\u9ad8\u6548\u5730\u8ddf\u8e2a\u8fd9\u4e9b\u8f6c\u5f55\u56e0\u5b50\u7684\u884c\u52a8\u3002<\/span><\/span><\/p><div><img src=\"https:\/\/p3-sign.toutiaoimg.com\/tos-cn-i-6w9my0ksvp\/6d6c0c7fadbf40aea8b8a779d975b5c4~tplv-obj.image?lk3s=ef143cfe&amp;traceid=20250512094914DF4955DFF708A2F84BC6&amp;x-expires=2147483647&amp;x-signature=G5FbYKtByV6HhaHlszQDtiDrnxY%3D\"\/>\u56fe | Seq2PRINT \u6355\u6349\u5230\u8f6c\u5f55\u56e0\u5b50\u5728 DNA \u4e0a\u7684\u7ed3\u5408\uff08\u6765\u6e90\uff1aNature\uff09<\/div><div><br\/><a><\/a><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u4f7f\u7528 ATAC-seq \u4ee5\u53ca Tn5 \u6d4b\u5b9a\u86cb\u767d\u7684\u7ed3\u5408\u4e5f\u63d0\u4f9b\u4e86\u4e00\u4e2a\u72ec\u7279\u7684\u673a\u4f1a\uff1aATAC-seq \u53ef\u4ee5\u5b8c\u7f8e\u5730\u548c\u5355\u7ec6\u80de\u6d4b\u5e8f\u7ed3\u5408\uff0c\u4ece\u800c\u80fd\u591f\u63d0\u4f9b\u5355\u4e2a\u7ec6\u80de\u5185 Tn5 \u5207\u5272 DNA \u7684\u4f4d\u7f6e\u6570\u636e\u3002\u8fd9\u4f7f\u5f97\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u5728\u5355\u7ec6\u80de\u6570\u636e\u96c6\u91cc\uff0c\u901a\u8fc7\u8ba1\u7b97\u751f\u7269\u5b66\u7684\u65b9\u6cd5\uff0c\u6765\u627e\u5230\u4e0d\u540c\u7684\u7ec6\u80de\u7c7b\u578b\u6216\u8005\u7ec6\u80de\u72b6\u6001\u3002\u5e76\u80fd\u4f7f\u7528 PRINT\/seq2PRINT \u8ffd\u8e2a\u86cb\u767d\u5728\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u548c\u72b6\u6001\u4e0b\u7684\u7ed3\u5408\u4f4d\u70b9\u53d8\u5316\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u7814\u7a76\u4e2d\uff0c\u4ed6\u4eec\u4f7f\u7528 SHARE-seq \u9488\u5bf9\u4eba\u7c7b\u9aa8\u9ad3\u6837\u672c\u8fdb\u884c\u6d4b\u5e8f\uff0c\u83b7\u5f97\u4e86\u63a5\u8fd1\u4e5d\u5341\u4e07\u4e2a\u7ec6\u80de\u7684 RNA \u4ee5\u53ca ATAC-seq \u7684\u591a\u7ec4\u5b66\u6570\u636e\uff0c\u6db5\u76d6\u4e86\u4ece\u9020\u8840\u5e72\u7ec6\u80de\u5230\u5404\u79cd\u5206\u5316\u72b6\u6001\u7684\u8840\u7ec6\u80de\u5728\u5185\u7684\u591a\u79cd\u7ec6\u80de\u7c7b\u578b\u3002\u57fa\u4e8e\u6b64\u6570\u636e\uff0c\u4ed6\u4eec\u4f7f\u7528 seq2PRINT \u8ffd\u8e2a\u4e86\u8f6c\u5f55\u56e0\u5b50\u548c\u5176\u4ed6\u8c03\u63a7\u86cb\u767d\u5728\u4e0d\u540c\u5206\u5316\u9636\u6bb5\u7684\u7ed3\u5408\u4f4d\u70b9\uff0c\u89e3\u7801\u4e86\u8f6c\u5f55\u56e0\u5b50\u5728\u5206\u5316\u8fc7\u7a0b\u4e2d\u7684\u7ed3\u5408\u53d8\u5316\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u4f20\u7edf\u4f7f\u7528 ATAC-seq \u7684\u7814\u7a76\u666e\u904d\u5173\u6ce8\u6bcf\u4e2a\u8c03\u63a7\u5143\u4ef6\u5728\u5173\u95ed\/\u6253\u5f00\u4e24\u4e2a\u72b6\u6001\u95f4\u7684\u5207\u6362\uff0c\u800c\u672c\u6b21\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff1a\u5728\u4e0d\u540c\u7ec6\u80de\u72b6\u6001\u4e0b\uff0c\u6bcf\u4e2a\u5355\u72ec\u7684\u8c03\u63a7\u5143\u4ef6\u53ef\u4ee5\u88ab\u591a\u79cd\u4e0d\u540c\u7ec4\u5408\u7684\u8f6c\u5f55\u56e0\u5b50\u7ed3\u5408\uff0c\u4ece\u800c\u5448\u73b0\u51fa\u5728\u6253\u5f00\/\u5173\u95ed\u4e4b\u5916\u591a\u4e2a\u66f4\u590d\u6742\u7684\u8c03\u63a7\u72b6\u6001\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u6b64\u5916\uff0c\u4ed6\u4eec\u8fd8\u89c2\u5bdf\u5230\u4e86\u542f\u52a8\u5b50\u548c\u589e\u5f3a\u5b50\u5728\u7ea2\u7ec6\u80de\u5206\u5316\u8fc7\u7a0b\u4e2d\u9010\u6b65\u5efa\u7acb\u7684\u8fc7\u7a0b\uff0c\u4ee5\u53ca\u4e0d\u540c\u8f6c\u5f55\u56e0\u5b50\u6309\u987a\u5e8f\u62b5\u8fbe DNA \u7684\u8fc7\u7a0b\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u6700\u540e\uff0c\u4ed6\u4eec\u4f7f\u7528 PRINT\/seq2PRINT \u6765\u7814\u7a76\u5c0f\u9f20\u9020\u8840\u5e72\u7ec6\u80de\u8870\u8001\u8fc7\u7a0b\u4e2d\u57fa\u56e0\u8c03\u63a7\u7684\u53d8\u5316\uff0c\u501f\u6b64\u53d1\u73b0\u8bb8\u591a\u8f6c\u5f55\u56e0\u5b50\u5728\u8870\u8001\u8fc7\u7a0b\u4e2d\u7ed3\u5408\u4f4d\u70b9\u589e\u52a0\u4f8b\u5982 Gata\u3001AP-1\u3001Runx \u7b49\uff0c\u5e76\u53d1\u73b0\u4e86\u8bb8\u591a\u8f6c\u5f55\u56e0\u5b50\u7684\u7ed3\u5408\u4e0b\u964d\u4f8b\u5982 Yy1\u3001Ctcf\u3001\u548c Nrf1 \u7b49\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u5229\u7528 Seq2PRINT \u4ed6\u4eec\u8fd8\u6355\u6349\u5230\u4e86\u4e0d\u540c TF \u4f5c\u4e3a\u4f34\u4fa3\u5171\u540c\u7ed3\u5408 DNA \u7684\u884c\u4e3a\uff0c<\/span><strong><span style=\"color: rgb(14, 23, 50); --tt-darkmode-color: #94A2CE;\">\u5c24\u5176\u4ee5 Runx \u548c Ets \u56e0\u5b50\u4f5c\u4e3a\u4e8c\u805a\u4f53\u5171\u540c\u7ed3\u5408 DNA \u5e76\u4e14\u968f\u8870\u8001\u4e0a\u8c03\u7684\u8fd9\u4e00\u884c\u4e3a\u6700\u4e3a\u5178\u578b\uff0c\u8fd9\u9884\u793a\u7740\u8fd9\u4e9b\u56e0\u5b50\u53ef\u80fd\u5728\u5e72\u7ec6\u80de\u8870\u8001\u4e2d\u53d1\u6325\u4f5c\u7528\u3002<\/span><\/strong><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u603b\u800c\u8a00\u4e4b\uff0cPRINT\/seq2PRINT \u4e3a\u7814\u7a76\u57fa\u56e0\u8c03\u63a7\u3001\u5c24\u5176\u662f\u4e3a\u7814\u7a76 DNA \u8c03\u63a7\u5143\u4ef6\u548c\u8f6c\u5f55\u56e0\u5b50\u63d0\u4f9b\u4e86\u6709\u529b\u7684\u65b0\u5de5\u5177\uff0c\u53ef\u4ee5\u8ba9\u4eba\u4eec\u5728\u66f4\u9ad8\u7684\u5206\u8fa8\u7387\u548c\u7cbe\u5ea6\u4e0b\u89c2\u6d4b\u57fa\u56e0\u8c03\u63a7\u7684\u8fc7\u7a0b\uff0c\u5e76\u4e3a\u53d1\u80b2\u548c\u518d\u751f\u751f\u7269\u5b66\u4ee5\u53ca\u75be\u75c5\u548c\u8870\u8001\u76f8\u5173\u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u65b0\u7684\u673a\u4f1a\u3002<\/span><\/span><\/p><div><img src=\"https:\/\/p3-sign.toutiaoimg.com\/tos-cn-i-6w9my0ksvp\/b0611e52bd9b4d75b2e879c00576447b~tplv-obj.image?lk3s=ef143cfe&amp;traceid=20250512094914DF4955DFF708A2F84BC6&amp;x-expires=2147483647&amp;x-signature=PPm3xhfXRxTIcJ%2BHpZwWfrRy7%2Fs%3D\"\/>\uff08\u6765\u6e90\uff1aNature\uff09<\/div><div><br\/><a><\/a><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u7814\u7a76\u4eba\u5458\u5e0c\u671b\u672c\u6b21\u6280\u672f\u53ef\u4ee5\u5e2e\u52a9\u66f4\u591a\u7684\u79d1\u5b66\u5bb6\u63ed\u793a\u8f6c\u5f55\u56e0\u5b50\u5982\u4f55\u5728\u4e0d\u540c\u7684\u7ec6\u80de\u3001\u7ec4\u7ec7\u548c\u5668\u5b98\u91cc\u8c03\u63a7\u57fa\u56e0\u8868\u8fbe\uff0c\u4ece\u800c\u5e2e\u52a9\u4ed6\u4eec\u53d1\u73b0\u8f6c\u5f55\u56e0\u5b50\u7684\u65b0\u529f\u80fd\uff0c\u4ee5\u53ca\u627e\u5230\u9a71\u52a8\u75be\u75c5\u8fdb\u7a0b\u7684\u8f6c\u5f55\u56e0\u5b50\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u4e8b\u5b9e\u4e0a\uff0c\u5728\u672c\u6b21\u7814\u7a76\u4e4b\u524d\uff0c\u5df2\u7ecf\u6709\u5176\u4ed6\u7814\u7a76\u4f7f\u7528 DNase I \u548c MNase \u7b49\u4e0d\u540c\u7684\u9176\u6765\u901a\u8fc7 DNA \u8db3\u8ff9\u6cd5\u786e\u5b9a\u86cb\u767d\u8d28\u5728 DNA \u4e0a\u7684\u7ed3\u5408\u4f4d\u7f6e\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u65b9\u6cd5\u90fd\u5f88\u96be\u548c\u5355\u7ec6\u80de\u6d4b\u5e8f\u7684\u65b9\u6cd5\u6574\u5408\u5728\u4e00\u8d77\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u4e00\u76f4\u4ee5\u6765\uff0c\u8be5\u56e2\u961f\u90fd\u5e0c\u671b\u53ef\u4ee5\u5c06 DNA \u8db3\u8ff9\u6cd5\u548c\u5355\u7ec6\u80de\u65b9\u6cd5\u52a0\u4ee5\u7ed3\u5408\uff0c\u4ee5\u4fbf\u7814\u7a76\u542b\u6709\u590d\u6742\u7ec6\u80de\u7c7b\u578b\u7684\u751f\u7269\u7cfb\u7edf\u5185\u5404\u4e2a\u7ec6\u80de\u7c7b\u578b\u7684\u57fa\u56e0\u8c03\u63a7\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u7531\u4e8e\u8fd1\u5e74\u6765\u5355\u7ec6\u80de ATAC-seq\uff08single cell ATAC-seq, scATAC-seq\uff09\u7684\u6280\u672f\u9010\u6e10\u6210\u719f\uff0c\u4ee5\u53ca\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u7684\u5feb\u901f\u8fdb\u6b65\uff0c\u4ed6\u4eec\u610f\u8bc6\u5230\u773c\u4e0b\u662f\u4e00\u4e2a\u4f7f\u7528 ATAC-seq \u6765\u5b9e\u73b0\u5355\u7ec6\u80de\u6570\u636e\u4e0a\u7684\u86cb\u767d\u8d28\u7ed3\u5408\u68c0\u6d4b\u7684\u597d\u65f6\u673a\uff0c\u57fa\u4e8e\u6b64\u4ed6\u4eec\u542f\u52a8\u4e86\u672c\u6b21\u8bfe\u9898\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u7814\u7a76\u4e2d\uff0c\u4ed6\u4eec\u7684\u65e9\u671f\u5de5\u4f5c\u4e3b\u8981\u96c6\u4e2d\u4e8e\u5982\u4f55\u53bb\u9664 Tn5 \u672c\u8eab\u5e8f\u5217\u504f\u597d\u7684\u5e72\u6270\uff0c\u4ee5\u53ca\u5efa\u7acb\u53ef\u9760\u7684\u7edf\u8ba1\u6a21\u578b\u68c0\u6d4b\u86cb\u767d\u8d28\u7684\u7ed3\u5408\u3002\u7ecf\u8fc7\u4e00\u756a\u52aa\u529b\uff0c\u4ed6\u4eec\u5efa\u7acb\u4e86\u4e00\u4e2a\u6709\u6548\u7684\u65b9\u6cd5\uff0c\u4ece\u800c\u80fd\u591f\u51c6\u786e\u5730\u68c0\u6d4b\u4e0d\u540c\u5c3a\u5bf8\u86cb\u767d\u8d28\u5728 DNA \u4e0a\u7684\u7ed3\u5408\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u5728\u8bfe\u9898\u7684\u4e2d\u540e\u671f\uff0c\u4e00\u4e2a\u4e00\u76f4\u96be\u4ee5\u89e3\u51b3\u7684\u95ee\u9898\u662f\uff1a\u68c0\u6d4b\u7ed3\u5408\u529b\u8f83\u5f31\u6216\u8005\u7ed3\u5408\u65f6\u95f4\u8f83\u77ed\u7684\u8f6c\u5f55\u56e0\u5b50\u3002\u8fd9\u4e9b\u8f6c\u5f55\u56e0\u5b50\u5e76\u4e0d\u4f1a\u5bf9 DNA \u6709\u8db3\u591f\u5f3a\u7684\u4fdd\u62a4\uff0c\u56e0\u6b64\u5728\u5b83\u4eec\u7684\u4fe1\u53f7\u91cc\u4e5f\u6ca1\u6709\u7559\u4e0b\u663e\u8457\u7684\u201c\u811a\u5370\u201d\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u7814\u7a76\u4eba\u5458\u4e00\u5ea6\u8ba4\u4e3a\u53ef\u80fd\u6ca1\u6709\u529e\u6cd5\u901a\u8fc7 ATAC-seq \u6765\u68c0\u6d4b\u5b83\u4eec\u7684\u5b58\u5728\uff0c\u76f4\u5230\u6709\u4e00\u5929\u7814\u7a76\u4eba\u5458\u7a81\u7136\u6709\u4e86\u4e00\u4e2a\u60f3\u6cd5\uff1a\u4e5f\u8bb8\u8fd9\u4e9b\u201c\u9690\u5f62\u201d\u7684\u8f6c\u5f55\u56e0\u5b50\u548c\u5176\u4ed6\u80fd\u7559\u4e0b\u53ef\u89c1\u8db3\u8ff9\u7684\u86cb\u767d\u8d28\u4e4b\u95f4\u6709\u8db3\u591f\u5f3a\u7684\u4f9d\u8d56\u548c\u7ea6\u675f\u5173\u7cfb\uff0c\u4ee5\u81f3\u4e8e\u4e5f\u8bb8\u53ef\u4ee5\u901a\u8fc7 AI \u7684\u5e2e\u52a9\uff0c\u5229\u7528\u53ef\u89c1\u7684\u4fe1\u53f7\u6765\u9884\u6d4b\u8fd9\u4e9b\u4e0d\u53ef\u89c1\u7684\u86cb\u767d\u7684\u7ed3\u5408\u72b6\u6001\uff1f<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u9488\u5bf9\u8fd9\u4e2a\u60f3\u6cd5\u7684\u5b9e\u73b0\u65b9\u6cd5\uff0c\u8bfe\u9898\u7ec4\u8fed\u4ee3\u4e86\u8bb8\u591a\u7248\u672c\u3002\u6700\u7ec8\uff0c\u4ed6\u4eec\u53d1\u73b0\u4f7f\u7528 DNA \u5e8f\u5217\u9884\u6d4b\u53ef\u89c1\u86cb\u767d\u8db3\u8ff9\u7684\u6a21\u578b seq2PRINT\uff0c\u80fd\u591f\u6355\u6349\u5230\u8fd9\u79cd\u4ed6\u4eec\u9884\u5224\u5df2\u4e45\u7684\u4f9d\u8d56\u5173\u7cfb\uff0c\u5e76\u4e14\u53ef\u4ee5\u51c6\u786e\u5730\u9884\u6d4b\u5230\u201c\u9690\u5f62\u201d\u8f6c\u5f55\u56e0\u5b50\u7684\u7ed3\u5408\u4f4d\u7f6e\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u540c\u65f6\uff0c\u8fd9\u4e5f\u662f\u56e0\u4e3a\u4ed6\u4eec\u6700\u5f00\u59cb\u6784\u5efa seq2PRINT \u53ea\u662f\u4e3a\u4e86\u7814\u7a76 DNA \u5e8f\u5217\u548c\u86cb\u767d\u7ed3\u5408\u7684\u4f9d\u8d56\u5173\u7cfb\uff0c\u800c\u5e76\u4e0d\u662f\u4e3a\u4e86\u9884\u6d4b\u8f6c\u5f55\u56e0\u5b50\u7684\u7ed3\u5408\u3002\u201c\u6240\u4ee5\uff0c\u8fd9\u4e5f\u7b97\u662f\u901a\u8fc7\u975e\u5e38\u9884\u6599\u4e4b\u5916\u7684\u65b9\u5f0f\u89e3\u51b3\u4e86\u6211\u4eec\u7684\u95ee\u9898\u3002\u201d\u80e1\u5f66\u8868\u793a\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u65e5\u524d\uff0c\u76f8\u5173\u8bba\u6587\u4ee5\u300a\u591a\u5c3a\u5ea6\u8db3\u8ff9\u63ed\u793a\u4e86\u987a\u5f0f\u8c03\u63a7\u5143\u4ef6\u7684\u7ec4\u7ec7\u300b\uff08Multiscale footprints reveal the organization of cis-regulatory elements\uff09\u4e3a\u9898\u53d1\u5728&nbsp;<\/span><\/span><em><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">Nature<\/span><\/span><\/em><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">[1]\uff0c\u535a\u58eb\u751f\u80e1\u5f66\u3001\u535a\u58eb\u540e\u5f20\u82e5\u9a70\u3001\u535a\u58eb\u540e\u9ea6\u514b\u601d\u00b7\u970d\u5c14\u8d1d\u514b\uff08Max Horlbeck \uff09\u4e3a\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u54c8\u4f5b\u5927\u5b66\u6770\u68ee\u00b7D\u00b7\u5e03\u6069\u7f57\u65af\u6258\uff08Jason D. Buenrostro\uff09\u6559\u6388\u62c5\u4efb\u901a\u8baf\u4f5c\u8005\u3002<\/span><\/span><\/p><div><img src=\"https:\/\/p3-sign.toutiaoimg.com\/tos-cn-i-6w9my0ksvp\/6361e94743fd4cc0a22eafbb103ace4b~tplv-obj.image?lk3s=ef143cfe&amp;traceid=20250512094914DF4955DFF708A2F84BC6&amp;x-expires=2147483647&amp;x-signature=EngrMZjdNThlCQMHqvkzebAwkcE%3D\"\/>\u56fe | \u76f8\u5173\u8bba\u6587\uff08\u6765\u6e90\uff1aNature\uff09<\/div><div><br\/><a><\/a><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u672a\u6765\uff0c\u80e1\u5f66\u5e0c\u671b\u80fd\u5c06\u672c\u6b21\u6280\u672f\u7528\u4e8e\u4eba\u7c7b\u75be\u75c5\u7814\u7a76\uff0c\u4f8b\u5982\u5fc3\u8840\u7ba1\u75be\u75c5\u9886\u57df\uff0c\u5373\u7814\u7a76\u57fa\u56e0\u8c03\u63a7\u5143\u4ef6\u548c\u8f6c\u5f55\u56e0\u5b50\u5728\u5fc3\u8840\u7ba1\u75be\u75c5\uff0c\u5c24\u5176\u662f\u7814\u7a76\u8870\u8001\u76f8\u5173\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\u3002<\/span><\/span><\/p><p><span style=\"letter-spacing: 1px;\"><span style=\"--tt-darkmode-color: #A3A3A3;\">\u540c\u65f6\uff0c\u5176\u5e0c\u671b\u901a\u8fc7\u5c06\u672c\u6b21\u6280\u672f\u7528\u4e8e\u5fc3\u8840\u7ba1\u7cfb\u7edf\u7684\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u6570\u636e\uff0c\u6765\u7814\u7a76\u5230\u5e95\u662f\u54ea\u4e9b\u57fa\u56e0\u3001\u54ea\u4e9b\u901a\u8def\u548c\u54ea\u4e9b\u8f6c\u5f55\u56e0\u5b50\u53c2\u4e0e\u4e86\u75be\u75c5\u53d1\u751f\u548c\u53d1\u5c55\u7684\u91cd\u8981\u6b65\u9aa4\u3002\u6700\u7ec8\uff0c\u5176\u5e0c\u671b\u53ef\u4ee5\u5f00\u53d1\u51fa\u80fd\u591f\u9884\u9632\u6216\u6cbb\u7597\u8870\u8001\u76f8\u5173\u75be\u75c5\u7684\u65b0\u65b9\u6cd5\u3002<\/span><\/span><\/p><p style=\"line-height: 1;\"><span style=\"letter-spacing: 1px;\"><span style=\"color: rgb(178, 178, 178); --tt-darkmode-color: #A3A3A3;\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/span><\/p><p style=\"line-height: 1;\"><span style=\"letter-spacing: 1px;\"><span style=\"color: rgb(178, 178, 178); --tt-darkmode-color: #A3A3A3;\">1.Hu, Y., Horlbeck, M.A., Zhang, R. et al. Multiscale footprints reveal the organization of cis-regulatory elements.&nbsp;<\/span><\/span><em><span style=\"letter-spacing: 1px;\"><span style=\"color: rgb(178, 178, 178); --tt-darkmode-color: #A3A3A3;\">Nature&nbsp;<\/span><\/span><\/em><span style=\"letter-spacing: 1px;\"><span style=\"color: rgb(178, 178, 178); --tt-darkmode-color: #A3A3A3;\">638, 779\u2013786 (2025). https:\/\/doi.org\/10.1038\/s41586-024-08443-4<\/span><\/span><\/p><p style=\"line-height: 1;\"><\/p><p style=\"line-height: 1;\"><span style=\"letter-spacing: 1px;\"><span style=\"color: rgb(178, 178, 178); --tt-darkmode-color: #A3A3A3;\">\u8fd0\u8425\/\u6392\u7248\uff1a\u4f55\u6668\u9f99<\/span><\/span><\/p><\/div><\/div><\/div><\/div><\/div>","content_en":null,"content_all":null,"article_url":"http:\/\/www.sciphi.cn\/article\/view\/14772","typeName":"\u79d1\u6280"},"code":10000,"message":"\u6210\u529f"}