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T \u7ec6\u80de\u542b\u91cf\u6b63\u76f8\u5173\uff08\u6765\u6e90\uff1aAdvanced Science\uff09\u65e5\u524d\uff0c\u76f8\u5173\u8bba\u6587\u4ee5\u300a\u9ad8\u6548\u514d\u75ab\u6cbb\u7597\u9884\u6d4b\u56e0\u5b50\uff1a\u57fa\u4e8e\u5168\u80bf\u7624\u6297\u539f\u7eb3\u7c73\u9897\u7c92\u68c0\u6d4b\u8840\u6db2\u4e2d\u591a\u514b\u9686\u6548\u5e94\u6027\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027 T \u7ec6\u80de\u300b\uff08Efficient Predictor for Immunotherapy Efficacy: Detecting Pan-Clones Effector Tumor Antigen-Specific T Cells in Blood by Nanoparticles Loading Whole Tumor Antigens\uff09\u4e3a\u9898\u53d1\u8868\u5728 Advanced Science[1]\u3002\u82cf\u5dde\u5927\u5b66\u66fe\u60df\u6807\u535a\u58eb\u548c\u7855\u58eb\u751f\u738b\u9526\u4e3a\u5e76\u5217\u7b2c\u4e00\u4f5c\u8005\uff0c\u8d75\u519b\u4e3b\u4efb\u3001\u5218\u5bc6\u6559\u6388\u548c\u7ae5\u65b0\u535a\u58eb\u62c5\u4efb\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002\u53e6\u4e00\u7bc7\u8bba\u6587\u4ee5\u300a\u98df\u7ba1\u764c\u60a3\u8005\u514d\u75ab\u6cbb\u7597\u9ad8\u6548\u751f\u7269\u6807\u5fd7\u7269\uff1a\u8840\u6db2\u4e2d\u591a\u514b\u9686\u6548\u5e94\u6027\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027 T \u7ec6\u80de\u7684\u68c0\u6d4b\u300b\uff08Efficient Biomarker for Immunotherapy: Measuring Broad Clones Effector Tumor Antigen-Specific T Cells in the Blood of Esophageal Cancer Patients\uff09\u4e3a\u9898\u53d1\u8868\u5728 Analytical Chemistry[2]\u3002\u82cf\u5dde\u5927\u5b66\u738b\u9526\u3001\u66fe\u60df\u6807\u535a\u58eb\u3001\u859b\u59e3\u535a\u58eb\u662f\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u5218\u5bc6\u6559\u6388\u3001\u8d75\u519b\u4e3b\u4efb\u548c\u79e6\u9882\u5175\u4e3b\u4efb\u62c5\u4efb\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002\u56fe\u4e28\u76f8\u5173\u8bba\u6587\uff08\u6765\u6e90\uff1aAdvanced Science\u3001Analytical Chemistry\uff09\u53c2\u8003\u8d44\u6599\uff1a1. Zeng,W. et al. Efficient Predictor for Immunotherapy Efficacy: Detecting Pan-Clones Effector Tumor Antigen-Specific T Cells in Blood by Nanoparticles Loading Whole Tumor Antigens. Advanced Science(2024).https:\/\/doi.org\/10.1002\/advs.2024099132. Wang,J. et al. Efficient Biomarker for Immunotherapy: Measuring Broad Clones Effector Tumor Antigen-Specific T Cells in the Blood of Esophageal Cancer Patients. Analytical Chemistry 96,48,19056\u201319065(2024).https:\/\/doi.org\/10.1021\/acs.analchem.4c04049\u8fd0\u8425\/\u6392\u7248\uff1a\u4f55\u6668\u9f99","content":"

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\u8fd1\u5e74\u6765\uff0c\u764c\u75c7\u514d\u75ab\u7597\u6cd5\uff08\u5982 PD-1 \u6297\u4f53\u3001PD-L1 \u6297\u4f53\u548c CAR-T \u7ec6\u80de\u7597\u6cd5\u7b49\uff09\u5df2\u6210\u4e3a\u764c\u75c7\u6cbb\u7597\u7684\u4e00\u7ebf\u7597\u6cd5\u3002\u7136\u800c\uff0c\u9700\u8981\u4e86\u89e3\u7684\u662f\uff0c\u8be5\u7597\u6cd5\u4ec5\u5bf9\u90e8\u5206\u60a3\u8005\u6709\u6548\uff0c\u4e14\u73b0\u6709\u68c0\u6d4b\u65b9\u6cd5\u9884\u6d4b\u7597\u6548\u5b58\u5728\u5c40\u9650\u6027\uff0c\u56e0\u6b64\u5f00\u53d1\u80fd\u591f\u9884\u6d4b\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7597\u6548\u7684\u65b0\u578b\u6807\u5fd7\u7269\u663e\u5f97\u5c24\u4e3a\u91cd\u8981\u3002<\/span><\/span><\/p>

\u76ee\u524d\u4e34\u5e8a\u4e0a\u7684\u68c0\u6d4b\u6280\u672f\u591a\u805a\u7126\u4e8e\u80bf\u7624\u7ec6\u80de\u76f8\u5173\u7684\u6307\u6807\uff0c\u5982\u68c0\u6d4b PD-L1 \u8868\u8fbe\u3001\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\u3001\u57fa\u56e0\u68c0\u6d4b\u3001\u5faa\u73af\u80bf\u7624\u7ec6\u80de\u68c0\u6d4b\uff0c\u4ee5\u53ca\u5faa\u73af\u80bf\u7624\u7ec6\u80de DNA \u68c0\u6d4b\u7b49\u3002<\/span><\/span><\/p>

\u5218\u5bc6\u8868\u793a\uff0c\u8981\u6218\u80dc\u80bf\u7624\u7ec6\u80de\uff0c\u5173\u952e\u662f\u8981\u201c\u77e5\u5df1\u77e5\u5f7c\u201d\u3002\u7136\u800c\u73b0\u6709\u7684\u8fd9\u4e9b\u65b9\u6cd5\u4ec5\u505a\u5230\u4e86\u201c\u77e5\u5f7c\u201d\u800c\u672a\u201c\u81ea\u77e5\u201d\uff0c\u76ee\u524d\u5c1a\u7f3a\u4e4f\u80fd\u591f\u5168\u9762\u51c6\u786e\u68c0\u6d4b\u81ea\u8eab\u514d\u75ab\u7cfb\u7edf\u5bf9\u80bf\u7624\u7ec6\u80de\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\u80fd\u529b\u7684\u6280\u672f\u3002<\/span><\/span><\/p>

ETAST \u662f\u673a\u4f53\u7279\u5f02\u6027\u8bc6\u522b\u548c\u7279\u5f02\u6027\u6740\u4f24\u764c\u7ec6\u80de\u7684\u201c\u4e3b\u529b\u519b\u201d\uff0c\u5176\u6570\u91cf\u548c\u6d3b\u6027\u6700\u80fd\u53cd\u5e94\u764c\u75c7\u60a3\u8005\u7684\u80bf\u7624\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\u80fd\u529b\u3002<\/span><\/span><\/p>

\u8be5\u56e2\u961f\u521b\u65b0\u6027\u5730\u5f00\u53d1\u4e86\u4e00\u79cd\u57fa\u4e8e\u8d1f\u8f7d\u764c\u7ec6\u80de\u5168\u7ec6\u80de\u6297\u539f\u7684\u7eb3\u7c73\u7c92\u7684 ETAST \u68c0\u6d4b\u6280\u672f\uff0c\u901a\u8fc7\u6fc0\u6d3b\u5916\u5468\u8840\u4e2d\u7684 ETAST \u5e76\u7ed3\u5408\u6d41\u5f0f\u7ec6\u80de\u672f\u68c0\u6d4b\uff0c\u80fd\u591f\u5168\u9762\u51c6\u786e\u5730\u68c0\u6d4b\u5176\u542b\u91cf\u3002<\/span><\/span><\/p>

\u5927\u591a\u6570\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u6cbb\u7597\u764c\u75c7\uff0c\u662f\u901a\u8fc7\u6fc0\u6d3b\u60a3\u8005\u4f53\u5185\u9884\u5b58\u5df2\u6709\u7684\u6548\u5e94\u6027 ETAST \u6216\u523a\u6fc0\u4ea7\u751f\u65b0\u7684 ETAST \u6765\u53d1\u6325\u4f5c\u7528\u7684\u3002\u56e0\u6b64\uff0cETAST \u7684\u542b\u91cf\u53ef\u7528\u4e8e\u8868\u5f81\u514d\u75ab\u6cbb\u7597\u6548\u679c\u3002<\/span><\/span><\/p>

\u6bcf\u4e00\u79cd\uff081 \u4e2a\u514b\u9686\uff09T \u7ec6\u80de\u53ea\u80fd\u7279\u5f02\u6027\u8bc6\u522b\u4e00\u79cd\u6297\u539f\uff0c\u800c\u764c\u75c7\u60a3\u8005\u4f53\u5185\u7684\u80bf\u7624\u6297\u539f\u79cd\u7c7b\u9884\u4f30\u6709 104-106 \u79cd\uff0c\u56e0\u800c\u53ef\u80fd\u4f1a\u523a\u6fc0\u60a3\u764c\u673a\u4f53\u4ea7\u751f\u6210\u5343\u4e0a\u4e07\u79cd\u4e0d\u540c\u7684 ETAST\u3002<\/span><\/span><\/p>

\u8981\u60f3\u5168\u9762\u51c6\u786e\u68c0\u6d4b\u51fa\u5404\u79cd\u4e0d\u540c\u7684 ETAST\uff0c\u5c31\u9700\u8981\u5c06\u5404\u7c7b ETAST \u4e0e\u5176\u4ed6 T \u7ec6\u80de\u90fd\u533a\u5206\u5f00\u6765\u3002\u4f46\u662f\uff0c\u5982\u4f55\u5c06\u6210\u5343\u4e0a\u4e07\u79cd\u4e0d\u540c\u7684 ETAST \u4ece\u5176\u4ed6\u4f17\u591a\u7684 T \u7ec6\u80de\u4e2d\u533a\u5206\u51fa\u6765\u662f\u4e00\u5927\u96be\u9898\u3002<\/span><\/span><\/p>

<\/div>
\uff08\u6765\u6e90\uff1aAnalytical Chemistry\uff09<\/div>
<\/a>

\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027 T \u7ec6\u80de\u68c0\u6d4b\u6280\u672f\u7684\u5177\u4f53\u8fc7\u7a0b\u5982\u4e0b\uff1a<\/span><\/span><\/p>

\u9996\u5148\uff0c\u6536\u53d6\u5f85\u68c0\u6d4b\u6837\u672c\u5916\u5468\u8840\u3001\u813e\u7ec6\u80de\u3001\u6dcb\u5df4\u7ed3\u7ec4\u7ec7\u6216\u8005\u80bf\u7624\u7ec4\u7ec7\u3002<\/span><\/span><\/p>

\u5176\u6b21\uff0c\u5206\u79bb\u5f97\u5230\u5916\u5468\u8840\u5355\u4e2a\u6838\u7ec6\u80de\u3001\u813e\u7ec6\u80de\u5355\u7ec6\u80de\u60ac\u6db2\u3001\u6dcb\u5df4\u7ed3\u7ec6\u80de\u5355\u7ec6\u80de\u60ac\u6db2\u6216\u80bf\u7624\u7ec4\u7ec7\u5355\u7ec6\u80de\u60ac\u6db2\u3002<\/span><\/span><\/p>

\u63a5\u7740\uff0c\u5c06\u4e0a\u8ff0\u6b65\u9aa4\u5236\u5907\u7684\u5f85\u68c0\u6d4b\u6837\u672c\u4e0e\u8d1f\u8f7d\u5168\u7ec6\u80de\u6297\u539f\u7684\u7eb3\u7c73\u7c92\u5b50\u68c0\u6d4b\u8bd5\u5242\u5171\u5b75\u80b2, \u8fd9\u4e9b\u7eb3\u7c73\u7c92\u5b50\u8d1f\u8f7d\u4e86\u6574\u4e2a\u80bf\u7624\u7684\u5168\u7ec6\u80de\u6297\u539f\uff0c\u80fd\u591f\u8bc6\u522b\u4efb\u4f55\u4e00\u79cd\u80bf\u7624\u6297\u539f\u7684 T \u7ec6\u80de\u90fd\u4f1a\u88ab\u6fc0\u6d3b\u3002<\/span><\/span><\/p>

\u6700\u540e\uff0c\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u68c0\u6d4b\u6fc0\u6d3b\u7684\u7279\u5f02\u6027 T \u7ec6\u80de\u7684\u542b\u91cf\u3002<\/span><\/span><\/p>

\u5b9e\u9645\u4e0a\uff0c\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027 T \u7ec6\u80de\u4e0e\u5176\u4ed6 T \u7ec6\u80de\u5728\u7ed3\u6784\u4e0a\u5e76\u6ca1\u6709\u660e\u663e\u7684\u5dee\u5f02\uff0c\u56e0\u6b64\u5982\u4f55\u533a\u5206\u5b83\u4eec\u5145\u6ee1\u6311\u6218\u3002\u5218\u5bc6\u8868\u793a\uff1a\u201c\u901a\u8fc7\u8fd9\u79cd\u65b0\u65b9\u6cd5\uff0c\u6211\u4eec\u5c06\u7ed3\u6784\u4e0a\u7684\u5dee\u5f02\u8f6c\u5316\u4e3a\u4e86\u6fc0\u6d3b\u6001\uff08\u8bc6\u522b\u80bf\u7624\u6297\u539f\u540e\u7684 ETAST\uff09\u4e0e\u975e\u6fc0\u6d3b\u6001\uff08\u5176\u4ed6 T \u7ec6\u80de\uff09\u7684\u5dee\u5f02\u3002\u56e0\u6b64\uff0c\u53ea\u6709\u80fd\u591f\u7279\u5f02\u6027\u8bc6\u522b\u80bf\u7624\u6297\u539f\u7684 T \u7ec6\u80de\u624d\u4f1a\u88ab\u6fc0\u6d3b\uff0c\u4ece\u800c\u5b9e\u73b0 ETAST \u7684\u7cbe\u51c6\u68c0\u6d4b\u3002\u201d<\/span><\/span><\/p>

\u56fe\u4e28Analytical Chemistry \u5f53\u671f\u5c01\u9762\u8bba\u6587\uff08\u6765\u6e90\uff1aAnalytical Chemistry\uff09<\/div>
<\/a>

\u6839\u636e\u7814\u7a76\u7ed3\u679c\uff0c\u764c\u75c7\u60a3\u8005\u5916\u5468\u8840\u4e2d\u7684 ETAST \u542b\u91cf\u663e\u8457\u9ad8\u4e8e\u5065\u5eb7\u4eba\u5916\u5468\u8840\u4e2d\u7684 ETAST \u542b\u91cf\u3002\u800c\u4e14\uff0c\u6cbb\u7597\u6548\u679c\u4e0e\u764c\u75c7\u60a3\u8005\u5916\u5468\u8840\u4e2d\u7684 ETAST \u542b\u91cf\u5448\u6b63\u76f8\u5173\u3002<\/span><\/span><\/p>

\u4e5f\u5c31\u662f\u8bf4\uff0c\u53ea\u6709\u5f53\u514d\u75ab\u6cbb\u7597\u6709\u6548\u65f6\uff0c\u764c\u75c7\u60a3\u8005\u5916\u5468\u8840\u4e2d\u7684 ETAST \u542b\u91cf\u624d\u4f1a\u4e0a\u5347\uff0c\u5355\u7ec6\u80de\u6d4b\u5e8f\u7ed3\u679c\u4e5f\u8bc1\u5b9e\u4e86\u8fd9\u4e00\u7ed3\u8bba\u3002<\/span><\/span><\/p>

<\/a>

\u6709\u671b\u5728\u836f\u6548\u8bc4\u4f30\u548c\u7597\u6548\u76d1\u6d4b\u7b49\u9886\u57df\u5e7f\u6cdb\u5e94\u7528<\/span><\/strong><\/span><\/p>

<\/p>

\u8be5\u65b9\u6cd5\u7684\u6f5c\u5728\u5e94\u7528\u573a\u666f\u5e7f\u6cdb\uff0c\u6db5\u76d6\u836f\u6548\u8bc4\u4f30\u3001\u6cbb\u7597\u8fc7\u7a0b\u76d1\u6d4b\u548c\u6cbb\u7597\u540e\u76d1\u6d4b\u7b49\u3002<\/span><\/span><\/p>

\u5728\u836f\u6548\u8bc4\u4f30\u65b9\u9762\uff0c\u901a\u8fc7\u5bf9\u6bd4\u7528\u836f\u524d\u540e\u7684\u764c\u75c7\uff08\u80bf\u7624\u6297\u539f\uff09\u7279\u5f02\u6027 T \u7ec6\u80de\u542b\u91cf\uff0c\u53ef\u8bc4\u4f30\u653e\u7597\u3001PD-1 \u6297\u4f53\u3001PD-L1 \u6297\u4f53\u7b49\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u3001\u764c\u75c7\u75ab\u82d7\u7b49\u514d\u75ab\u6cbb\u7597\u65b9\u6cd5\u7684\u6548\u679c\u3002<\/span><\/span><\/p>

\u5728\u6cbb\u7597\u8fc7\u7a0b\u76d1\u6d4b\u4e2d\uff0c\u8be5\u6280\u672f\u80fd\u5728\u653e\u7597\u3001\u514d\u75ab\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u76d1\u6d4b\u764c\u75c7\u60a3\u8005\u5916\u5468\u8840\u4e2d\u764c\u75c7\uff08\u80bf\u7624\u6297\u539f\uff09\u7279\u5f02\u6027 T \u7ec6\u80de\u7684\u6c34\u5e73\u53d8\u5316\uff0c\u4e3a\u7597\u6548\u8bc4\u4f30\u548c\u60a3\u8005\u514d\u75ab\u72b6\u6001\u76d1\u6d4b\u63d0\u4f9b\u5ba2\u89c2\u4f9d\u636e\u3002<\/span><\/span><\/p>

\u5728\u6cbb\u7597\u540e\u76d1\u6d4b\u4e2d\uff0c\u901a\u8fc7\u5b9e\u65f6\u8ffd\u8e2a\u60a3\u8005\u6cbb\u6108\u540e\u5b9a\u671f\u68c0\u6d4b\u764c\u75c7\uff08\u80bf\u7624\u6297\u539f\uff09\u7279\u5f02\u6027 T \u7ec6\u80de\u542b\u91cf\uff0c\u65e2\u53ef\u8bc4\u4f30\u673a\u4f53\u514d\u75ab\u7cfb\u7edf\u5bf9\u764c\u75c7\u7684\u514d\u75ab\u76d1\u89c6\u80fd\u529b\uff0c\u9884\u6d4b\u764c\u75c7\u590d\u53d1\u51e0\u7387\uff0c\u53c8\u80fd\u9884\u6d4b\u590d\u53d1\u98ce\u9669\u5e76\u6307\u5bfc\u5e72\u9884\u63aa\u65bd\u7684\u5236\u5b9a\u3002<\/span><\/span><\/p>

<\/div>
\u56fe\u4e28\u98df\u7ba1\u764c\u60a3\u8005\u514d\u75ab\u6cbb\u7597\u7597\u6548\u4e0e\u5916\u5468\u8840\u4e2d\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027 T \u7ec6\u80de\u542b\u91cf\u6b63\u76f8\u5173\uff08\u6765\u6e90\uff1aAnalytical Chemistry\uff09<\/div>
<\/a>

\u76ee\u524d\uff0c\u8be5\u56e2\u961f\u5df2\u7ecf\u5728\u82cf\u5dde\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u5b8c\u6210\u80ba\u764c\u548c\u98df\u7ba1\u764c\u4e2d\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u6b63\u5728\u66f4\u591a\u764c\u79cd\u4e2d\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8be5\u6280\u672f\u62e5\u6709\u5168\u7403\u8303\u56f4\u5185\u72ec\u5bb6\u4e13\u5229\uff0c\u56fd\u5185\u548c\u65e5\u672c\u7684\u6838\u5fc3\u4e13\u5229\u5df2\u7ecf\u6388\u6743\uff0c\u4e14\u4e13\u5229\u5df2\u8fdb\u5165\u7f8e\u56fd\u3001\u6b27\u76df\u3001\u52a0\u62ff\u5927\u3001\u6fb3\u5927\u5229\u4e9a\u7b49\u5e02\u573a\u3002<\/span><\/span><\/p>

\u9664\u4e34\u5e8a\u5e94\u7528\u5916\uff0c\u8fd8\u6280\u672f\u8fd8\u53ef\u7528\u4e8e\u65b0\u836f\u7814\u53d1\u3001\u8054\u5408\u7528\u836f\u65b9\u6848\u4f18\u5316\u3001\u6eb6\u7624\u75c5\u6bd2\u7597\u6cd5\u8bc4\u4f30\u3001\u75ab\u82d7\u5f00\u53d1\u53ca\u5149\u70ed\u6cbb\u7597\u7b49\u9886\u57df\u3002\u800c\u4e14\uff0c\u672a\u6765\u8fd8\u6709\u671b\u4f5c\u4e3a\u4e00\u79cd\u975e\u4fb5\u5165\u6027\u68c0\u6d4b\u65b9\u6cd5\uff0c\u7528\u4e8e\u826f\u6027\/\u6076\u6027\u80ba\u7ed3\u8282\u6216\u4e73\u817a\u7ed3\u8282\u7684\u8f85\u52a9\u8bca\u65ad\uff0c\u4ece\u800c\u51cf\u5c11\u548c\u907f\u514d\u4e0d\u5fc5\u8981\u7684\u7a7f\u523a\u7b49\u521b\u4f24\u6027\u68c0\u67e5\u3002<\/span><\/span><\/p>

\u56fe\u4e28\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u514d\u75ab\u6cbb\u7597\u7597\u6548\u4e0e\u5916\u5468\u8840\u4e2d\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027 T \u7ec6\u80de\u542b\u91cf\u6b63\u76f8\u5173\uff08\u6765\u6e90\uff1aAdvanced Science\uff09<\/div>
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\u65e5\u524d\uff0c\u76f8\u5173\u8bba\u6587\u4ee5\u300a\u9ad8\u6548\u514d\u75ab\u6cbb\u7597\u9884\u6d4b\u56e0\u5b50\uff1a\u57fa\u4e8e\u5168\u80bf\u7624\u6297\u539f\u7eb3\u7c73\u9897\u7c92\u68c0\u6d4b\u8840\u6db2\u4e2d\u591a\u514b\u9686\u6548\u5e94\u6027\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027 T \u7ec6\u80de\u300b\uff08Efficient Predictor for Immunotherapy Efficacy: Detecting Pan-Clones Effector Tumor Antigen-Specific T Cells in Blood by Nanoparticles Loading Whole Tumor Antigens\uff09\u4e3a\u9898\u53d1\u8868\u5728 <\/span><\/span>Advanced Science<\/span><\/span><\/em>[1]\u3002<\/span><\/span><\/p>

\u82cf\u5dde\u5927\u5b66\u66fe\u60df\u6807\u535a\u58eb\u548c\u7855\u58eb\u751f\u738b\u9526\u4e3a\u5e76\u5217\u7b2c\u4e00\u4f5c\u8005\uff0c\u8d75\u519b\u4e3b\u4efb\u3001\u5218\u5bc6\u6559\u6388\u548c\u7ae5\u65b0\u535a\u58eb\u62c5\u4efb\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002<\/span><\/span><\/p>

\u53e6\u4e00\u7bc7\u8bba\u6587\u4ee5\u300a\u98df\u7ba1\u764c\u60a3\u8005\u514d\u75ab\u6cbb\u7597\u9ad8\u6548\u751f\u7269\u6807\u5fd7\u7269\uff1a\u8840\u6db2\u4e2d\u591a\u514b\u9686\u6548\u5e94\u6027\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027 T \u7ec6\u80de\u7684\u68c0\u6d4b\u300b\uff08Efficient Biomarker for Immunotherapy: Measuring Broad Clones Effector Tumor Antigen-Specific T Cells in the Blood of Esophageal Cancer Patients\uff09\u4e3a\u9898\u53d1\u8868\u5728 <\/span><\/span>Analytical Chemistry<\/span><\/span><\/em>[2]\u3002<\/span><\/span><\/p>

\u82cf\u5dde\u5927\u5b66\u738b\u9526\u3001\u66fe\u60df\u6807\u535a\u58eb\u3001\u859b\u59e3\u535a\u58eb\u662f\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c\u5218\u5bc6\u6559\u6388\u3001\u8d75\u519b\u4e3b\u4efb\u548c\u79e6\u9882\u5175\u4e3b\u4efb\u62c5\u4efb\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002<\/span><\/span><\/p>

\u56fe\u4e28\u76f8\u5173\u8bba\u6587\uff08\u6765\u6e90\uff1aAdvanced Science\u3001Analytical Chemistry\uff09<\/div>
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1. Zeng,W. et al. Efficient Predictor for Immunotherapy Efficacy: Detecting Pan-Clones Effector Tumor Antigen-Specific T Cells in Blood by Nanoparticles Loading Whole Tumor Antigens. <\/span><\/span>Advanced Science<\/span><\/span><\/em>(2024).<\/span><\/span><\/p>

https:\/\/doi.org\/10.1002\/advs.202409913<\/span><\/span><\/p>

2. Wang,J. et al. Efficient Biomarker for Immunotherapy: Measuring Broad Clones Effector Tumor Antigen-Specific T Cells in the Blood of Esophageal Cancer Patients.<\/span><\/span> Analytical Chemistry <\/span><\/span><\/em>96,48,19056\u201319065(2024).<\/span><\/span><\/p>

https:\/\/doi.org\/10.1021\/acs.analchem.4c04049<\/span><\/span><\/p>

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